Call for Proposals

Xcellomics is seeking novel, in vitro or ex vivo, pathologically relevant cellular assays that have the potential to be developed into small molecule or functional genomic CRISPR screens. We are encouraging members of the research community to submit proposals in the following disease areas:

ONCOLOGY

We are seeking screens to identify novel oncology targets in a cancer population with high unmet need

Proposed screens must: 

  • Focus on a specific cancer type(s)/genetic background(s)/resistance to SOC/etc. that
    continues to be challenging to treat in the clinic

  • Exclude rare and pediatric cancers

  • Screen type = CRISPR functional genomics screen or arrayed compound library screen

  • Use a cell-based assay with disease relevant cancer model(s)

  • Not duplicate a screen that has already been published

At the application stage, we are only looking for non-confidential information on the screen. NDAs will be put in place for any more detailed discussions.

Eligibility & Selection Criteria

  • The following must be met for applications to be eligible for consideration:

    • Proposals can only be submitted by individuals affiliated with or employed by an academic or research institution.

    • Screening assays must be relevant to human disease and preferably include near-patient cellular models.

    • Screening assays must have the potential to be transferred to Oxford’s Centres for Medicines Discovery and developed into medium- to high-throughput automated screens.

    • Relevance of the screen in identifying novel drug targets for a cancer type(s) with high unmet clinical need

    • Novelty of the screen design

    • Disease relevance and robustness of the cellular model(s) used

    • Feasibility of assay development into automated medium and high throughput screening formats

How to Apply

Submitting an application to the Xcellomics program is quick and easy.

  1. Download the application form

  2. Provide us with the details of your proposed screen by completing all fields on the application form. Incomplete forms may not be considered.

  3. Submit your completed application form by email to xcellomics@exscientia.co.uk

DOWNLOAD APPLICATION